now that; since; so long as; because
Expresses 'now that' or 'since' a certain situation exists, the speaker feels a strong obligation or determination to follow through.
からには is used when you acknowledge a fact or decision, and from that point on, you have a strong sense of duty, commitment, or inevitability. It often appears in sentences where the speaker expresses resolve, like 'since I've decided to do this, I will do my best.' It is more forceful and personal than just saying から, because it emphasizes that the situation cannot be undone.