Nihoner

“Once-in-a-lifetime” in Japanese

Short answer
千載一遇 senzaiichiguu senzaiichiguu

Once-in-a-lifetime in Japanese is “千載一遇” (senzaiichiguu). Full meaning: once-in-a-lifetime (opportunity), golden (opportunity), one-in-a-million (chance).

Other ways to say “Once-in-a-lifetime” in Japanese

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