This pattern is used to say that even if you do a certain action, it won't lead to any meaningful result—it's pointless, hopeless. It often appears in complaints or when accepting an unpleasant situation. The phrase どうにもならない means 'cannot be helped' or 'nothing can be done.' Together, it emphasizes that the action is futile.

You'll often hear it in spoken Japanese, but it's not rude; it's just a resigned expression. For example, if someone keeps worrying about a past mistake, you might say 後悔してもどうにもならない to tell them that regretting won't fix anything. Note that the ても part can also be でも after nouns and な-adjectives, as in 今さらでもどうにもならない.

The nuance is stronger than just saying 'no use'—it carries a sense of 'there's absolutely nothing we can do about it.' It's a set phrase used in both casual and formal speech, but it's more common in conversation than in writing.